National BioResource Project


cordBlood_imageCord blood stem cells for research

Last update: June 12, 2017 

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cordBloodStemCell_Database
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Center

Department of Cell Processing and Transfusion, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo

NAGAMURA Tokiko
E-mail

〒108-8639  4-6-1, Shiroganedai, Minato-ku
Tel : 03-5449-5527
Fax : 03-5449-5452

Objectives

Human cord blood stem cells (CBSC) (Figure) are known to contain the most premature hematopoietic stem cells as well as mesenchymal stem cells. CBSCs have been clinically used as the source of hematopoietic stem cell transplantation for severe hematologic diseases like leukemia, and they are now widely used for research purposes in the medical and biological studies of regenerative medicine, drug development, epidemiology, infection, genetics and environmental studies.
This project provides fresh or frozen cord blood stem cells that are not suitable for transplant purpose and transferred from three cord blood banks of the Japan Cord Blood Bank Network (Tokyo, Tokai University and Hyogo CB Banks) with written consent to researchers through the RIKEN BRC.

Organization

Flow chart of cord blood

Available Resources

Distribution / Deposition

Distribution
Deposition

Research Result

Kuroda T, Yasuda S, Kusakawa S, Hirata N, Kanda Y, Suzuki K, Takahashi M, Nishikawa S, Kawamata S, Sato Y. Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells. PLoS One. 2012;7(5):e37342.
Naoki Nishishita, Masayuki Shikamurab, Chiemi Takenaka, Nozomi Takadab, Noemi Fusaki, and Shin Kawamata. Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naive state. PLoS One. 2012;7(6):e38389.
Sato Y, Nagata S, Takiguchi M. Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1. PLoS One. 2012;7(8):e42776.
Miharada K, Nakamura Y. In vitro production of enucleated red blood cells from hematopoietic stem and progenitor cells. Methods Mol Biol. 2012;879:505-12.
Rie Ozeki, Sei Kakinuma, Kinji Asahina, Keiko Shimizu-Saito, Shigeki Arii,Yujiro Tanaka and Hirobumi Teraoka. Hepatic stellate cells mediate differentiation of dendritic cells from monocytes. J Med Dent Sci 2012;59:43-52.
Moriya K, Suzuki M, Watanabe Y, Takahashi T, Aoki Y, Uchiyama T, Kumaki S, Sasahara Y, Minegishi M, Kure S, Tsuchiya S, Sugamura K, Ishii N. Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice. PLoS One. 2012;7(6):e37892.
Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K. Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse.Int Immunol. 2012;24(4):243-52.
Fujiwara T, Alqadi YW, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.
Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells. 2013;31(3):458-66.
Kurita, R., Suda, N., Sudo, K., Miharada, K., Hiroyama, T., Miyoshi, H., Tani, K., and Nakamura, Y. Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells. PLoS One. 2013;8(3):e59890.
Shimizu A, Kobayashi N, Shimada K, Oura K, Tanaka T, Okamoto A, Kondo K. Novel gene therapy viral vector using non-oncogenic lymphotropic herpesvirus. PLoS One. 2013;8(2):e56027
Maeki T, Hayashi M, Kawabata A, Tang H, Yamanishi K, Mori Y. Identification of the human herpesvirus 6A gQ1 domain essential for its functional conformation. J Virol. 2013 Jun;87(12):7054-63.
F Hayakawa, K Sugimoto, Y Harada, N Hashimoto, N Ohi, S Kurahashi and T Naoe. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Blood Cancer J. 2013;3(11):e166.
Fujiwara T, Saitoh H, Inoue A, Kobayashi M, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Harigae H.3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosyl-methionine-dependent methyltransferase, promotes erythroid differentiation. J Biol Chem. 2014 Feb 3.

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