|Focus||Maintenance of whole genome sequences on related species of Aspergillus fumigatus|
|Principal Investigator||Takashi Yaguchi Chiba University|
Fungal infections to immunocompromised patients tend to be increased with aging and medical development in recent years, especially aspergillosis is the most important. Aspergillus fumigatus is the major etiologic agent of aspergillosis. Its related species, A. lentulus, A. viridinutans and A. udagawae have been also reported as causative agents of aspergillosis, and the numbers of cases are increasing. Their susceptibilities against antifungal drugs, especially azoles, are different from that of A. fumigatus. Therefore we are developing collections of these relative species and their data of susceptibilities against azoles.
In this project, we will analyze whole genome sequences on related species of A. fumigatus. Those data may be of help for elucidating the mechanisms resistant to antifungal agents, developing appropriate therapy in aspergillosis, and addressing the genetic diversity of Aspergillus species.
A, B. Aspergillus fumigatus. C, D. A. lentulus.